Answer the questions below and then click the button. The next page will mark your answers and show you how well you have done compared with the previous people who have taken the tests.
Which of the following would be classed as surrogate endpoints?
1) Time to death
2) Reduction in LDL cholesterol
3) Increase in specific antibody level in testing a new vaccine
4) Relief of pain at 2 hours post dose
If you considered that the new product that you were testing was probably as effective as the chosen comparator but may be a little better which would be the most suitable form of trial?
You are contemplating a trial design for your new product against one of three competitor products; product A, product B or product C. The primary endpoint of the trial would be complete pain relief at 2 hours. It is expected that 65% of patients taking the new product would achieve pain relief at 2 hours. It is also expected that the pain relief rates for products A, B and C at 2 hours would be 60%, 62% and 58%. If you were looking to show a statistically significant difference between your product and the comparator product which of the comparators would require the trial to have the least number of patients?
If you were looking for a guideline to provide some information about the choice of control group for your trial where would you look?
If you had a block size of 6. Two treatment groups A and B. The randomisation was a ratio of 2 to 1 with 2 in A and 1 in B. What would be the next two letters in the randomisation sequence following this:
AAAABBBAAB..?
