Answer the questions below and then click the button. The next page will mark your answers and show you how well you have done compared with the previous people who have taken the tests.
Which of the following could potentially reduce the sample size requirement when designing a clinical trial?
If the sample size calculations suggest a requirement for 1000 patients to complete the trial and the drop out rate is expected to be around 20%, how many patients would you recruit into the trial?
Which of the following is true about a trial that is designed with 80% power?
Which Guideline provides guidance on the re-assessment of the original assumptions of the power and sample size, including the test below:
"In long term trials there will usually be an opportunity to check the assumptions which underlay the original design and sample size calculations. This may be particularly important if the trial specifications have been made on preliminary and/or uncertain information."
When sample sizing some oncology trials, for example those using time to death as an endpoint, which of the following additional factors need to be considered to determine the sample size?
