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Weekly GCP Challenge

Answer the questions below and then click the button. The next page will mark your answers and show you how well you have done compared with the previous people who have taken the tests.


Challenge: Statistics in Protocols

Question Number 1:
Which of the following is not a method for adjusting for multiple statistical comparisons in the analysis of clinical trial data?
A
 Holm Step Down
B
 Mantel-Haenszel
C
 Hochberg Step Up
D
 Bonferroni

Question Number 2:
If a trial was designed so the type II error rate was to be 20% what would the statistical power of the trial be?
A
 5%
B
 20%
C
 80%
D
 95%

Question Number 3:
If a trial had the primary endpoint defined as survival (or time to death) which of the following would be the most appropriate summary measure to quantify the treatment effect between two treatments?
A
 Difference in means
B
 Hazard Ratio
C
 Geometric Mean
D
 Rate Ratio

Question Number 4:
Which of the following is the odd one out?
A
 t-test
B
 Chi Squared Test
C
 Fishers Exact Test
D
 Logistic Regression Analysis

Question Number 5:
If the analysis of a trial which compares two treatments, A and B, detected a qualitative treatment by centre interaction what would this mean?
A
 A is better than B in all centres
B
 B is better than A in all centres
C
 A is better than B in all centres but the size of the difference varies between centres
D
 A is better than B in some centres and B is better than A in others.

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